1.201J/11.545J/ESD.210J is required for all first-year Master of Science in Transportation students. It would be of interest to, as well as accessible to, students in Urban Studies and Planning, Political Science, Technology and Policy, Management, and various engineering departments. It is a good subject for those who plan to take only one subject in transportation and serves as an entry point to other transportation subjects as well. The subject focuses on fundamental principles of transportation systems, introduces transportation systems components and networks, and addresses how one invests in and operates them effectively. The tie between transportation and related systems is emphasized.

This course presents a unique and challenging perspective on the causes of human disease and mortality. The course focuses on analyses of major causes of mortality in the US since 1900: cancer cardiovascular and cerebrovascular diseases, diabetes, infectious diseases. Students create analytical models to derive estimates for historically variant population risk factors and physiological rate parameters, and conduct analyses of familial data to separately estimate inherited and environmental risks. The course evaluates the basic population genetics of dominant, recessive and non-deleterious inherited risk factors.

15.763 focuses on decision making for system design, as it arises in manufacturing systems and supply chains. Students are exposed to frameworks and models for structuring the key issues and trade-offs. The class presents and discusses new opportunities, issues and concepts introduced by the internet and e-commerce. It also introduces various models, methods and software tools for logistics network design, capacity planning and flexibility, make-buy, and integration with product development. Industry applications and cases illustrate concepts and challenges. Recommended for operations management concentrators. Second half-term subject.

This course covers basic topics in autonomous marine vehicles, focusing mainly on software and algorithms for autonomous decision making (autonomy) by underwater vehicles operating in the ocean environments, autonomously adapting to the environment for improved sensing performance. It will introduce students to underwater acoustic communication environment, as well as the various options for undersea navigation, both crucial to the operation of collaborative undersea networks for environmental sensing. Sensors for acoustic, biological and chemical sensing by underwater vehicles and their integration with the autonomy system for environmentally adaptive undersea mapping and observation will be covered. The subject will have a significant lab component, involving the use of the MOOS-IvP autonomy software infrastructure for developing integrated sensing, modeling and control solutions for a variety of ocean observation problems, using simulation environments and a field testbed with small autonomous surface craft and underwater vehicles operated on the Charles River.

The main objective is to provide students with a rational basis of the design of reinforced concrete members and structures through advanced understanding of material and structural behavior. This course is offered to undergraduate (1.054) and graduate students (1.541). Topics covered include: Strength and Deformation of Concrete under Various States of Stress; Failure Criteria; Concrete Plasticity; Fracture Mechanics Concepts; Fundamental Behavior of Reinforced Concrete Structural Systems and their Members; Basis for Design and Code Constraints; High-performance Concrete Materials and their use in Innovative Design Solutions; Slabs: Yield Line Theory; Behavior Models and Nonlinear Analysis; and Complex Systems: Bridge Structures, Concrete Shells, and Containments.

Introduction to continuum mechanics and material modeling of engineering materials based on first energy principles: deformation and strain; momentum balance, stress and stress states; elasticity and elasticity bounds; plasticity and yield design. Overarching theme is a unified mechanistic language using thermodynamics, which allows understanding, modeling and design of a large range of engineering materials.

This course provides an introduction to the study of environmental phenomena that exhibit both organized structure and wide variability - i.e., complexity. Through focused study of a variety of physical, biological, and chemical problems in conjunction with theoretical models, we learn a series of lessons with wide applicability to understanding the structure and organization of the natural world. Students will also learn how to construct minimal mathematical, physical, and computational models that provide informative answers to precise questions.

Presents a rational basis for the preliminary design of motion-sensitive structures. Topics include: analytical and numerical techniques for establishing the optimal stiffness distribution, the role of damping in controlling motion, tuned mass dampers, base isolation systems, and an introduction to active structural control. Examples illustrating the application of the motion-based design paradigm to building structures subjected to wind and seismic excitation are discussed.

The principles and practice of tissue engineering (and regenerative medicine) are taught by faculty of the Harvard-MIT Division of Health Sciences and Technology (HST) and Tsinghua University, Beijing, China. The principles underlying strategies for employing selected cells, biomaterial scaffolds, soluble regulators or their genes, and mechanical loading and culture conditions, for the regeneration of tissues and organs in vitro and in vivo are addressed. Differentiated cell types and stem cells are compared and contrasted for this application, as are natural and synthetic scaffolds. Methodology for the preparation of cells and scaffolds in practice is described. The rationale for employing selected growth factors is covered and the techniques for incorporating their genes into the scaffolds are examined. Discussion also addresses the influence of environmental factors including mechanical loading and culture conditions (e.g., static versus dynamic). Methods for fabricating tissue-engineered products and devices for implantation are taught. Examples of tissue engineering-based procedures currently employed clinically are analyzed as case studies.

Explores the interaction of radiation with matter at the microscopic level from both the theoretical and experimental viewpoints. Emphasis on radiation effects in biological systems. Topics include energy deposition by various types of radiation, including the creation and behavior of secondary radiations; the effects of radiation on cells and on DNA; and experimental techniques used to measure these radiation effects. Cavity theory, microdosimetry and methods used to simulate radiation track structure are reviewed. Examples of current literature used to relate theory, modeling, and experimental methods. Requires a term paper and presentation. The central theme of this course is the interaction of radiation with biological material. The course is intended to provide a broad understanding of how different types of radiation deposit energy, including the creation and behavior of secondary radiations; of how radiation affects cells and why the different types of radiation have very different biological effects. Topics will include: the effects of radiation on biological systems including DNA damage; in vitro cell survival models; and in vivo mammalian systems. The course covers radiation therapy, radiation syndromes in humans and carcinogenesis. Environmental radiation sources on earth and in space, and aspects of radiation protection are also discussed. Examples from the current literature will be used to supplement lecture material.

Quantitative analysis of uncertainty and risk for engineering applications. Fundamentals of probability, random processes, statistics, and decision analysis. Random variables and vectors, uncertainty propagation, conditional distributions, and second-moment analysis. Introduction to system reliability. Bayesian analysis and risk-based decision. Estimation of distribution parameters, hypothesis testing, and simple and multiple linear regressions. Poisson and Markov processes. Emphasis on application to engineering problems.

Project Evaluation covers methodologies for evaluating civil engineering projects, which typically are large-scale and long-lived and involve many economic, financial, social and environmental factors. The course places an emphasis on dealing with uncertainty. Students learn basic techniques of engineering economics, including net present value analysis, life-cycle costing, benefit-cost analysis, and other approaches to project evaluation. Examples are drawn from both contemporary and historical projects in various fields, including transportation systems, urban development, energy and environmental projects, water resource management, telecommunications systems, and other elements of the public and private projects and programs.

For the last century, precepts of scientific management and administrative rationality have concentrated power in the hands of technical specialists, which in recent decades has contributed to widespread disenfranchisement and discontent among stakeholders in natural resources cases. In this seminar we examine the limitations of scientific management as a model both for governance and for gathering and using information, and describe alternative methods for informing and organizing decision-making processes. We feature cases involving large carnivores in the West (mountain lions and grizzly bears), Northeast coastal fisheries, and adaptive management of the Colorado River. There will be nightly readings and a short written assignment.

This course examines joint fact-finding within the context of adaptive and ecosystem-based management. Challenges and obstacles to collaborative approaches for deciding environmental and natural resource policy and the institutional changes within federal agencies necessary to utilize joint fact-finding as a means to link science and societal decisions are discussed and reviewed with scientists and managers. Senior-level federal policymakers participate

Required for all Earth, Atmospheric, and Planetary Sciences majors in the Environmental Science track, this course is an introduction to current research in the field. Stresses integration of central scientific concepts in environmental policy making and the chemistry, biology, and geology environmental science tracks. Revisits selected core themes for students who have already acquired a basic understanding of environmental science concepts. The topic for this term is geoengineering.

1.050 is a sophomore-level engineering mechanics course, commonly labeled "Statics and Strength of Materials" or "Solid Mechanics I." This course introduces students to the fundamental principles and methods of structural mechanics. Topics covered include: static equilibrium, force resultants, support conditions, analysis of determinate planar structures (beams, trusses, frames), stresses and strains in structural elements, states of stress (shear, bending, torsion), statically indeterminate systems, displacements and deformations, introduction to matrix methods, elastic stability, and approximate methods. Design exercises are used to encourage creative student initiative and systems thinking.

Introduces students to basic properties of structural materials and behavior of simple structural elements and systems through a series of experiments. Students learn experimental technique, data collection, reduction and analysis, and presentation of results.

This landscape and environmental planning workshop investigates and propose a framework for the enhancement, development and preservation of the natural and cultural landscape of the Cardener River Corridor in Catalunya Spain. The workshop is carried out in conjunction with the Polytechnic University of Catalunya, and the Barcelona Provincial Council (DiputaciĚ_ de Barcelona).

12.103 explores the role of scientific knowledge, discovery, method, and argument in environmental policymaking from both idealistic and realistic perspectives. The course will use case studies of science-intensive environmental controversies to study how science was used and abused in the policymaking process. Case studies include: global warming, biodiversity loss, and nuclear waste disposal siting. Subject includes intensive practice in the writing and presentation of "position statements" on environmental science issues.

Examines the fundamental concepts of strategic planning and management in the context of the real estate, design, and construction industry. Discusses the basic business relationships among firms in the design and construction value chain. Specific topics include: industry analysis; strategic planning models; information technology strategy; strategy in fragmented industries; negotiation; and macro trends shaping the industry as a whole. Case method of instruction is used, and supplemented by extensive readings. From the course home page: This course provides an overview of key concepts in strategic management in the construction, real estate, and architecture industries. Topics include supply chain analysis, market segmentation, vertical integration, competitive advantage, and industry transformation. This course is of interest to students seeking more understanding of the business dynamics of real estate and construction; seeking to provide value in firms which they may join; or seeking to build a foundation for their own entrepreneurial pursuits.