By the end of this section, you will be able to:Describe the different types of variation in a populationExplain why only heritable variation can be acted upon by natural selectionDescribe genetic drift and the bottleneck effectExplain how each evolutionary force can influence the allele frequencies of a population

By the end of this section, you will be able to:Explain pharmacogenomicsDefine polygenic

By the end of this section, you will be able to:Describe gel electrophoresisExplain molecular and reproductive cloningDescribe uses of biotechnology in medicine and agriculture

By the end of this section, you will be able to:Explain systems biologyDescribe a proteomeDefine protein signature

By the end of this section, you will be able to:Define genomicsDescribe genetic and physical mapsDescribe genomic mapping methods

By the end of this section, you will be able to:Describe three types of sequencingDefine whole-genome sequencing

By the end of this section, you will be able to:Explain how the structure of DNA reveals the replication processDescribe the Meselson and Stahl experiments

By the end of this section, you will be able to:Discuss the different types of mutations in DNAExplain DNA repair mechanisms

By the end of this section, you will be able to:Discuss the similarities and differences between DNA replication in eukaryotes and prokaryotesState the role of telomerase in DNA replication

By the end of this section, you will be able to:Explain the process of DNA replication in prokaryotesDiscuss the role of different enzymes and proteins in supporting this process

By the end of this section, you will be able to:Describe the structure of DNAExplain the Sanger method of DNA sequencingDiscuss the similarities and differences between eukaryotic and prokaryotic DNA

By the end of this section, you will be able to:Explain transformation of DNADescribe the key experiments that helped identify that DNA is the genetic materialState and explain Chargaff’s rules

By the end of this section, you will be able to:Describe how changes to gene expression can cause cancerExplain how changes to gene expression at different levels can disrupt the cell cycleDiscuss how understanding regulation of gene expression can lead to better drug design

By the end of this section, you will be able to:Explain the process of epigenetic regulationDescribe how access to DNA is controlled by histone modification

By the end of this section, you will be able to:Understand RNA splicing and explain its role in regulating gene expressionDescribe the importance of RNA stability in gene regulation

By the end of this section, you will be able to:Discuss the role of transcription factors in gene regulationExplain how enhancers and repressors regulate gene expression

By the end of this section, you will be able to:Understand the process of translation and discuss its key factorsDescribe how the initiation complex controls translationExplain the different ways in which the post-translational control of gene expression takes place